Beat HIV

Are you interested in learning more about our HIV cure-directed clinical studies that are about to start?
If so, contact Ken Lynn, RN, at 215-662-8217 or kenneth.lynn@uphs.upenn.edu.

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Latest Study

Bruner KM, Wang Z, Siliciano RF, et al. “A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses” Nature.2019 Feb;566(7742):120-125. doi: 10.1038/s41586-019-0898-8. Epub 2019 Jan 30.

Kwaa AKR, Talana CAG, Blankson JN. “Interferon-α Enhances NK Cell Function and the Suppressive Capacity of HIV-specific CD8+ T Cells“. J Virol. 2019. 93(3), pii: e01541.

 

Einkauf KB, Lee GQ, Gao C, Sharaf R, Sun X, Hua S, Chen SMY, Jiang C, Lian X, Chowdhury FZ, Rosenberg ES, Chun T-W, Li JZ, Yu XG, Lichterfeld M. “Intact HIV-1 proviruses accumulate at distinct positions during prolonged antiretroviral therapy“. Journal of Clinical Investigation. 2019. 129(3): 988-998.

 

Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M. “Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption“. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11341-E11348. PMCID: PMC6275529.

 

Bar-On Y, Gruell H, Schoofs T, Pai JA, Nogueira L, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Karagounis T, Cohen YZ, Wyen C, Scholten S, Handl L, Belblidia S, Dizon JP, Vehreschild JJ, Witmer-Pack M, Shimeliovich I, Jain K, Fiddike K, Seaton KE, Yates NL, Horowitz J, Gulick RM, Pfeifer N, Tomaras GD, Seaman MS, Fätkenheuer G, Caskey M, Klein F, Nussenzweig MC. “Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals“. Nat Med. 2018 Nov;24(11):1701-1707. PMCID: PMC6221973.

 

Lada SM, Huang K, VanBelzen DJ, Montaner LJ, O’Doherty U, Richman DD. “Quantitation of Integrated HIV Provirus by Pulsed-Field Gel Electrophoresis and Droplet Digital PCR“. J Clin Microbiol. 2018 Nov 27;56(12). pii: e01158-18. PMCID: PMC6258838.

 

Colon K, Speicher DW, Smith P, Taylor M, Metzger DS, Montaner LJ, Tomescu C. “S100A14 is Increased in Activated NK cells and Plasma of HIV-Exposed Seronegative People Who inject Drugs and Promotes Monocyte-NK Crosstalk“. JAIDS. 2018. November 5. [Epub ahead of print].

 

Siliciano JD, Siliciano RF. “Assays to Measure Latency, Reservoirs, and Reactivation“. Top Microbiol Immunol. 2018; 417:23-41. PMID: 29071475.

 

Maldini CR, Ellis GI, Riley JL. “CAR T cells for infection, autoimmunity and allotransplantation“. Nat Rev Immunol. 2018 Oct;18(10):605-616. PMID: 30046149.

 

Cai Y, Abdel-Mohsen M, Tomescu C, Xue F, Wu G, Howell BJ, Yong AI, Sun J, Azzoni L, Le Coz C, Romberg N, Montaner LJ. “BCL6 Inhibitor-mediated Downregulation of pSAMHD1 and T Cell Activation Are Negatively Associated with HIV Infection and Reactivation“. Journal of Virology. 2018. October 24. [Epub ahead of print].

 

Spivak AM, Nell RA, Petersen M, Martins L, Sebahar P, Looper RE, Planelles V. “Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal“. Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01361-18. PMCID: PMC6201092.

 

Szaniawski MA, Spivak AM, Bosque A, Planelles V. “Sex influences SAMHD1 activity and susceptibility to HIV-1 in primary human macrophages“. J. Inf. Diseases. 2018. PMID 30299483.

 

Williams B, Boucher C, Bushman F, Carrington-Lawrence S, Collman R, Dandekar S, Dang Q, Malaspina A, Paredes R, Wilson C, Nowak P, Klatt N, Lagenaur L, Landay A. “A Summary of the Third Annual HIV Microbiome Workshop“. AIDS Res Hum Retroviruses. 2018 Oct;34(10):828-834. PMID: 30105916.

 

Vadrevu SK, Trbojevic-Akmacic I, Kossenkov AV, Colomb F, Giron LB, Anzurez A, Lynn K, Mounzer K, Landay AL, Kaplan RC, Papasavvas E, Montaner LJ, Lauc G, Abdel-Mohsen M. “Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy“. J Leukoc Biol. 2018 Sep;104(3):461-471. PMCID: PMC6113120.

 

Massanella M, Yek C, Lada SM, Nakazawa M, Shefa N, Huang K, Richman DD. “Improved assays to measure and characterize the inducible HIV reservoir“. EBioMedicine. 2018 Oct;36:113-121.

 

Xu Z, Wise MC, Choi H, Perales-Puchalt A, Patel A, Tello-Ruiz E, Chu JD, Muthumani K, Weiner DB. “Synethic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig“. EBioMedicine. 2018 Sep; 35:97-105. PMID:30174283.

 

Clarke EL, Connell AJ, Six E, Kadry NA, Abbas AA, Hwang Y, Everett JK, Hofstaedter CE, Marsh R, Armant M, Kelsen J, Notarangelo LD, Collman RG, Hacein-Bey-Abina S, Kohn DB, Cavazzana M, Fischer A, Williams DA, Pai SY, Bushman FD. “T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency“. Genome Med. 2018 Sep 28;10(1):70. PMCID: PMC6161392.

 

Veenhuis RT, Kwaa AK, Garliss CC, Latanich R, Salgado M, Pohlmeyer CW, Nobles CL, Gregg J, Scully EP, Bailey JR, Bushman FD, Blankson JN. “Long-term remission despite clonal expansion of replication-competent HIV-1 isolates“. JCI Insight. 2018 Sep 20;3(18). pii: 122795. [Epub ahead of print] PMID: 30232278.

 

Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O’Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC. “Combination therapy with anti-HIV-1 antibodies maintains viral suppression“. Nature. 2018 Sep;561(7724):479-484. PMCID: PMC6166473.

 

Bertagnolli LN, White JA, Simonetti FR, Beg SA, Lai J, Tomescu C, Murray AJ, Antar AAR, Zhang H, Margolick JB, Hoh R, Deeks SG, Tebas P, Montaner LJ, Siliciano RF, Laird GM, Siliciano JD.” The role of CD32 during HIV-1 infection“. Nature. 2018 Sep;561(7723):E17-E19. PMID: 30232425.

 

Cohen YZ, Lorenzi JCC, Krassnig L, Barton JP, Burke L, Pai J, Lu CL, Mendoza P, Oliveira TY, Sleckman C, Millard K, Butler AL, Dizon JP, Belblidia SA, Witmer-Pack M, Shimeliovich I, Gulick RM, Seaman MS, Jankovic M, Caskey M, Nussenzweig MC. “Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117“. J Exp Med. 2018 Sep 3;215(9):2311-2324. PMCID: PMC6122972.

 

Ecker C, Riley JL. “Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition“. Cell Metab. 2018 Aug 7;28(2):190-195. PMID: 30089240.

 

Tso FY, Kang G, Kwon EH, Julius P, Li Q, West JT, Wood C. “Brain is a potential sanctuary for subtype C HIV-1 irrespective of ART treatment outcome“. PLoS One. 2018 Jul 24;13(7):e0201325. PMCID: PMC6057662.

 

Cohen YZ, Caskey M. “Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection. Curr Opin HIV AIDS“. 2018 Jul;13(4):366-373. PMID: 29697469.

 

Salantes DB, Zheng Y, Mampe F, Srivastava T, Beg S, Lai J, Li JZ, Tressler RL, Koup RA, Hoxie J, Abdel-Mohsen M, Sherrill-Mix S, McCormick K, Overton ET, Bushman FD, Learn GH, Siliciano RF, Siliciano JM, Tebas P, Bar KJ. “HIV-1 latent reservoir size and diversity are stable following brief treatment interruption“. J Clin Invest. 2018 Jul 2;128(7):3102-3115. PMID: 29911997.

 

Papasavvas E, Lada SM, Joseph J, Yin X, Liu Q, Azzoni L, Mounzer K, Kostman JR, Richman D, Montaner LJ. “Analytical ART interruption does not irreversibly change pre-interruption levels of cellular HIV“. AIDS. 2018 Jun 11. PMCID: PMC6289896.

 

Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A, Planelles V. “SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition“. MBio. 2018 May 15;9(3). pii: e00819-18. PMCID: PMC5954222.

 

Sengupta S, Siliciano RF. “Targeting the Latent Reservoir for HIV-1“. Immunity. 2018 May 15;48(5):872-895. Review. PMCID: PMC6196732.

 

Cohn LB, da Silva IT, Valieris R, Huang AS, Lorenzi JCC, Cohen YZ, Pai JA, Butler AL, Caskey M, Jankovic M, Nussenzweig MC. “Clonal CD4(+) T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation“. Nat Med. 2018 May;24(5):604-609. PMCID: PMC5972543.

 

Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ. “CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells“. Sci Transl Med. 2018 Apr 18;10(437). pii: eaar6759. PMCID: PMC6282755.

 

Szaniawski, M.A., Spivak, A.M., Cox, J.E., Catrow, J.L., Hanley, T., Williams, ESCP., Tremblay, M.J., Bosque, A., Planelles, V. “SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition.” MBio. 2018 May 15;9(3). pii: e00819-18. doi: 10.1128/mBio.00819-18.

 

Ecker C, Guo L, Voicu S, Gil-de-Gomez L, Medvec A, Cortina L, Pajda J, Andolina M, Torres-Castillo M, Donato JL, Mansour S, Zynda ER, Lin PY, Varela-Rohena A, Blair IA, Riley JL. “Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments.” Cell Rep. 2018 Apr 17;23(3):741-755. doi: 10.1016/j.celrep.2018.03.084.

 

Vadrevu SK, Trbojevic-Akmacic I, Kossenkov AV, Colomb F, Giron LB, Anzurez A, Lynn K, Mounzer K, Landay AL, Kaplan RC, Papasavvas E, Montaner LJ, Lauc G, Abdel-Mohsen M. “Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy.” J Leukoc Biol. 2018 Apr 6. doi: 10.1002/JLB.3HI1217-500R. [Epub ahead of print]

 

Cohen YZ, Lorenzi JCC, Seaman MS, Nogueira L, Schoofs T, Krassnig L, Butler A, Millard K, Fitzsimons T, Daniell X, Dizon JP, Shimeliovich I, Montefiori DC, Caskey M, Nussenzweig MC. “Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells.” J Virol. 2018 Feb 12;92(5). pii: e01883-17. doi: 10.1128/JVI.01883-17. Print 2018 Mar 1.

 

Cummins NW, Rizza S, Litzow MR, Hua S, Lee GQ, Einkauf K, Chun TW, Rhame F, Baker JV, Busch MP, Chomont N, Dean PG, Fromentin R, Haase AT, Hampton D, Keating SM, Lada SM, Lee TH, Natesampillai S, Richman DD, Schacker TW, Wietgrefe S, Yu XG, Yao JD, Zeuli J, Lichterfeld M, Badley AD. “Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.” PLoS Med. 2017 Nov 28;14(11):e1002461. doi: 10.1371/journal.pmed.1002461. eCollection 2017 Nov.

 

Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. “HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.” PLoS Med. 2017 Nov 7;14(11):e1002417. doi: 10.1371/journal.pmed.1002417. eCollection 2017 Nov.

 

Spivak AM, Planelles V. “Novel Latency Reversal Agents for HIV-1 Cure.” Annu Rev Med. 2017 Nov 3. [Epub ahead of print.]

 

Leibman RS, Richardson MW, Ellebrecht CT, Maldini CR, Glover JA, Secreto AJ, et al. “Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.” PLoS Pathog. 2017;13(10): e1006613.

 

Mikulak J, Oriolo F, Zaghi E, Di Vito C, Mavilio D.” Natural Killer Cells in HIV-1 Infection and Therapy.” AIDS. 2017 Sep 18. doi: 10.1097/QAD.0000000000001645.

 

Kurachi M, Kurachi J, Chen Z, Johnson J, Khan O, Bengsch B, Stelekati E, Attanasio J, McLane LM, Tomura M, Ueha S, Wherry EJ. “Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function.” Nat Protoc. 2017 Sep;12(9):1980-1998. doi: 10.1038/nprot.2017.083. Epub 2017 Aug 31.

 

Yek C, Massanella M, Peling T, Lednovich K, Nair SV, Worlock A, Vargas M, Gianella S, Ellis RJ, Strain MC, Busch MP, Nugent T, Richman DC. “Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types.” J Clin Microbiol. 2017 August;55(8):2544-2553. doi: 10.1128/JCM.00425-17.

 

Honeycutt JB, Thayer WO, Baker CE, Ribeiro RM, Lada SM, Cao Y, Cleary RA, Hudgens MG, Richman DD, Garcia JV. “HIV Persistence in tissue macrophages of humanized mice during ART.” Nat Med. 2017 May;23(5):638-643. doi: 10.1038/nm.4319.

 

Pollack RA, Jones RB, Pertea M, Bruner KM, Martin AR, Thomas AS, Capoferri AA, Beg SA, Huang SH, Karandish S, Hao H, Halper-Stromberg E, Yong PC, Kovacs C, Benko E, Siliciano RF, Ho YC. “Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.Cell Host Microbe. 2017 Apr 12;21(4):494-506.e4. doi: 10.1016/j.chom.2017.03.008.

 

Hosmane NN, Kwon KJ, Bruner KM, Capoferri AA, Beg S, Rosenbloom DI, Keele BF, Ho YC, Siliciano JD, Siliciano RF. “Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics.” J Exp Med. 2017 Mar 24. pii: jem.20170193. doi: 10.1084/jem.20170193.

 

Mikulak J, Di Vito C, Zaghi E, Mavilio D. “Host Immune Responses in HIV-1 Infection: The Emerging Pathogenic Role of Siglecs and Their Clinical Correlates.” Front Immunol. 2017 Mar 23;8:314. doi: 10.3389/fimmu.2017.00314.

 

Riley JL, Montaner LJ. “Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir.” J Infect Dis. 2017 Mar 15;215(suppl_3):S160-S171. doi: 10.1093/infdis/jix002.

 

Martin AR, Pollack RA, Capoferri A, Ambinder RF, Durand CM, Siliciano RF. “Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity.” J Clin Invest. 2017 Feb 1;127(2):651-656. doi: 10.1172/JCI89552. PMID: 28094770

 

Tomescu C, Tebas P, Montaner. “IFN-α Augments NK-mediated Antibody-Dependent Cellular Cytotoxicity (ADCC) of HIV-1 Infected Autologous CD4+ T Cells Regardless of MHC-I Downregulation.” AIDS.  2017 Jan.  DOI: 10.1097/QAD.0000000000001380

 

Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O’Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F. “Antibody 10-1074 suppresses viremia in HIV-1 infected individuals.” Nat Med. 2017 Jan 16. doi: 10.1038/nm.4268. [Epub ahead of print] PMID: 28092665 [PubMed – as supplied by publisher]

 

Iyer SS, Bibollet-Ruche F, Sherrill-Mix S, Learn GH, Plenderleith L, Smith AG, Barbian HJ, Russell RM, Gondim MV, Bahari CY, Shaw CM, Li Y, Decker T, Haynes BF, Shaw GM, Sharp PM, Borrow P, Hahn BH. “Resistance to type I interferons is a major determinant of HIV-1 transmission fitness.” Proc Natl Acad Sci U S A. 2017 Jan 24;114(4): E590-E599. doi: 10.1073/pnas.1620144114. PMID: 28069935 [PubMed – in process]

 

Yuan Z, Kang G, Lu W, and Li Q. “Reactivation of HIV-1 proviruses in immune-compromised mice engrafted with human VOA-negative CD4+ T Cells.” J Virus Eradication. 2017; 3: 61-65.

 

Lorenzi JC, Cohen YZ, Cohn LB, Kreider EF, Barton JP, Learn GH, Oliveira T, Lavine CL, Horwitz JA, Settler A, Jankovic M, Seaman MS, Chakraborty AK, Hahn BH, Caskey M, Nussenzweig MC. “Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.” Proc Natl Acad Sci U S A. 2016 Dec 6;113(49): E7908-E7916. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 17.  PMID: 27872306 [PubMed – in process]

 

Bar KJ, Sneller MC, Harrison LJ, Justement JS, Overton ET, Petrone ME, Salantes DB, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Blazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden K, O’Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun TW. “Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.” N Engl J Med. 2016 Nov 24;375(21):2037-2050. PMID: 27959728 [PubMed – indexed for MEDLINE]